Campus Units

Zoology

Document Type

Article

Publication Version

Published Version

Publication Date

7-14-1997

Journal or Book Title

The Journal of Cell Biology

Volume

138

Issue

1

First Page

143

Last Page

157

DOI

10.1083/jcb.138.1.143

Abstract

By immunoaffinity purification with the mAb Lan3-2, we have identified two novel Ig superfamily members, Tractin and LeechCAM. LeechCAM is an NCAM/FasII/ApCAM homologue, whereas Tractin is a cleaved protein with several unique features that include a PG/YG repeat domain that may be part of or interact with the extracellular matrix. Tractin and LeechCAM are widely expressed neural proteins that are differentially glycosylated in sets and subsets of peripheral sensory neurons that form specific fascicles in the central nervous system. In vivo antibody perturbation of the Lan3-2 glycoepitope demonstrates that it can selectively regulate extension of neurites and filopodia. Thus, these experiments provide evidence that differential glycosylation can confer functional diversity and specificity to widely expressed neural proteins.

Comments

This article is published as Huang, Yueqiao, John Jellies, Kristen M. Johansen, and Jørgen Johansen. "Differential glycosylation of tractin and LeechCAM, two novel Ig superfamily members, regulates neurite extension and fascicle formation." The Journal of cell biology 138, no. 1 (1997): 143-157. doi: 10.1083/jcb.138.1.143. Posted with permission.

Copyright Owner

The Rockefeller University Press

Language

en

File Format

application/pdf

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